Endocrine Abstracts

Introduction: Mitochondrial uncoupling proteins (UCPs) are mitochondrial transmembrane channels belonging to the anion carrier family. Six UCP homologues (UCP1-6) had been identified with a ubiquitous distribution throughout the body and many different physiological functions. UCPs are important regulators of several biological processes, including thermogenesis, oxidative phosphorylation, ROS production, as well as cellular metabolism. However, the knowledge concerning the mo...

Diabetic nephropathy (DN) and insulin resistance (IR) in kidney cells are considered the main cause of end-stage renal failure. Additionally, hyperglycemia and increased fatty (FA) acids are observed in patients with type 2 diabetes mellitus, where lipid accumulation has been correlated to IR. Nonetheless, the impact of IR in early disease stages is still unclear. Moreover, proximal renal tubular cells have high mitochondrial content where aerobic respiration is their primary ...

Introduction: Mitochondrial uncoupling proteins (UCPs) are transmembrane channels present in the inner mitochondrial membrane whose function is the transport of protons and small substrates between the intermembrane space and the mitochondrial matrix. UCPs are key regulators of cellular metabolism, including mitochondrial function, oxidative phosphorylation, and reactive oxygen species (ROS) production. UCPs’ dysfunction has been associated with the onset of metabolic dis...

Background: Thionamides are a class of drugs used to control thyrotoxicosis. A wide range of systemic adverse effects have been described, including agranulocytosis, rash, fever, arthralgia, hepatitis and even drug-induced lupus. Besides, there are some uncommon events related to their use, such as pleural effusion (only eight cases have been previously reported). We report a case of methimazole-induced eosinophilic pleural effusion.Case: Our patient is ...

Introduction: DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome is a severe multiorgan drug reaction, often associated with the development of autoimmune diseases. Pathogenically it has been related to the reactivation or the primary infection of different herpes virus.Clinical case: A 33-year-old woman with a history of residual epilepsy, after resection of a cerebellar pleomorphic xantoastrocytoma, started treatment with Levetirace...

Introduction: Patients with primary adrenal insufficiency (PAI) require lifelong corticoids replacement and they are at risk of therapy-related osteoporosis and cardiovascular complications.Objectives: Determine the prevalence of cardiovascular risk factors, osteoporosis, and other toxicities related with corticoids treatment.Material and methods: Retrospective, descriptive study in patients with PAI follow up in our service during...

Introduction and objectives: Hyperglycemia is a common problem in hospitalized patients, that increases infections, mortality, costs and the hospital stay. The objective of this study is to know the prevalence of hyperglycemia in our hospital.Methods: We designed a cross-sectional observational study. We included patients admitted in the hospital every 3 days in 2 months. We excluded patients younger than 15 years, stays less than 3 days and those of the...

Introduction and objectives: Hyperglycemia (HG) is a common problem in hospitalized patients that increases infections, mortality, costs and the hospital stay. The objective of this study is to know the association of the HG with cardiovascular risk factors (CVRF), stress factors, hospital stay and mortality.Methods: We designed a cross-sectional observational study. We included patients admitted in the hospital every three days in two months. We exclude...

Introduction and objectives: Hyperglycemia (HG) is a common problem in hospitalized patients that increases infections, mortality, costs and the hospital stay. The objective of this study is to know the association of the HG with cardiovascular risk factors (CVRF), stress factors, hospital stay and mortality.Methods: We designed a cross-sectional observational study. We included patients admitted in the hospital every three days in two months. We exclude...

Introduction and objectives: Hyperglycemia is a common problem in hospitalized patients that increases infections, mortality, costs and the hospital stay. The objective of this study is to know the management and control of hyperglycemia in our hospital.Methods: We designed a cross-sectional observational study. We included patients admitted in the hospital every three days in two months. We excluded patients younger than 15 years, stays less than three ...